Funds/iShares

iShares Healthcare Innovation UCITS ETF USD (Acc)

IE00BYZK4776ETFUSDAccumulatingFigures as of 2026-09-25
Global Health Care Equity
RiskMediumValuationGrowthConcentrationDiversifiedRegionGlobal · United States tiltSectorHealth Care

iShares Healthcare Innovation UCITS ETF USD (Acc) is a global health care equity etf from iShares with a total expense ratio of 0.40% and a risk indicator of 4 on the 1–7 scale. Its ten largest positions weigh 20.7% of the portfolio, which FundFacts classifies as diversified. Regional focus: Global with a United States tilt. Sector tilt: Health Care.

Key facts

TER0.40%
Fund sizeUSD 1.5bn
Inception2016-09-08
Holdings200
Asset classEquities
BenchmarkSTOXX GLOBAL BREAKTHROUGH HEALTHCARE (Net)

Risk indicator (SRRI)

1
2
3
4
5
6
7
Lower risk · lower rewardHigher risk · higher reward
Volatility 3y17.38%
Sharpe 3y0.53
Max drawdown-18.4%

Investment objective

The Fund aims to achieve a return on your investment, through a combination of capital growth and income on the Fund’s assets, which reflects the return of the STOXX Global Breakthrough Healthcare Index, the Fund’s benchmark index (the Index) The Fund is passively managed, and aims to invest in equity securities (e.g. shares) that, so far as possible and practicable, make up the Index.

Fund details

ISINIE00BYZK4776
Fund houseiShares
StructureETF
Share class currencyUSD
Distribution policyAccumulating
DomicileIreland
Launch date2016-09-08
BenchmarkSTOXX GLOBAL BREAKTHROUGH HEALTHCARE (Net)
ReplicationPhysical
SFDR classificationArticle 8
Asset classEquities
Fund sizeUSD 1.5bn
Number of holdings200
Equity / bond split100 / 0
Price / earnings25.7x

Fees and costs

Total expense ratio (TER)0.40%
Ongoing charges0.40%
Transaction costs0.02%
Entry charge0.00%
Exit charge0.00%
Performance fee0.00%
Reduction in yield, 1 year0.40%
Reduction in yield, holding period0.40%
Recommended holding period5 years

Growth of 100 since inception

10015020020182020202220242026
Fund215STOXX GLOBAL BREAKTHROUGH HEALTHCARE (Net)220
2016-09 → 2026-09 · rebased to 100
Computed from the NAV history the issuer publishes, monthly observations, rebased to 100 at the first point.

Calendar-year returns

+52.1%2020−6.0%2021−23.6%2022+2.1%2023+1.4%2024+18.5%2025
Fund STOXX GLOBAL BREAKTHROUGH HEALTHCARE (Net)

Annualised returns

PeriodFundIndexDiff
1 Year+37.21%+37.45%−0.24%
3 Years p.a.+17.20%+17.38%−0.18%
5 Years p.a.+0.83%+1.04%−0.21%
10 Years p.a.+7.86%+8.07%−0.21%
Since Inception+7.94%+8.16%−0.22%

Largest sectors

  1. Health Care98.1%
  2. Information Technology1.1%
  3. Industrials0.5%
  4. Real Estate0.2%

Largest countries

  1. United States71.5%
  2. Switzerland5.1%
  3. Japan4.6%
  4. Korea (South)3.6%
  5. Other3.0%
  6. Denmark2.6%
  7. Belgium2.4%
  8. Germany1.8%
  9. United Kingdom1.5%
  10. China1.4%

Concentration

Top 10 weight 20.7% — diversified
  1. 01MODERNA5.06%
  2. 02NATERA2.25%
  3. 03ILLUMINA INC2.04%
  4. 04IQVIA HOLDINGS1.76%
  5. 05REVVITY1.71%
  6. 06GENMAB1.69%
  7. 07GUARDANT HEALTH1.65%
  8. 08AGILENT TECHNOLOGIES INC1.55%
  9. 09MERCK & CO INC1.51%
  10. 10ROIVANT SCIENCES LTD1.50%
Full holdings (200) in the API payload.

Frequently asked questions

What is the TER of iShares Healthcare Innovation UCITS ETF USD (Acc)?

The total expense ratio (TER) of iShares Healthcare Innovation UCITS ETF USD (Acc) (IE00BYZK4776) is 0.40% per year.

How risky is iShares Healthcare Innovation UCITS ETF USD (Acc)?

iShares Healthcare Innovation UCITS ETF USD (Acc) has a risk indicator (SRRI) of 4 on a scale from 1 (lower risk) to 7 (higher risk), which FundFacts places in the medium risk band. Its 3-year volatility is 17.38%. Its maximum drawdown is -18.4%.

What are the top holdings of iShares Healthcare Innovation UCITS ETF USD (Acc)?

The largest positions of iShares Healthcare Innovation UCITS ETF USD (Acc) as of 2026-09-25 are MODERNA (5.06%), NATERA (2.25%), ILLUMINA INC (2.04%), IQVIA HOLDINGS (1.76%) and REVVITY (1.71%). Its ten largest holdings make up 20.7% of the portfolio, out of 200 holdings in total.

What does iShares Healthcare Innovation UCITS ETF USD (Acc) invest in?

iShares Healthcare Innovation UCITS ETF USD (Acc) is a global health care equity etf. Its largest exposures as of 2026-09-25 are by country, United States 71.5%, Switzerland 5.1% and Japan 4.6%; by sector, Health Care 98.1%, Information Technology 1.1% and Industrials 0.5%.

How has iShares Healthcare Innovation UCITS ETF USD (Acc) performed?

iShares Healthcare Innovation UCITS ETF USD (Acc) returned +37.21% over one year, +0.83% a year over five years and +18.5% in calendar year 2025 as of 2026-09-25, according to the NAV history iShares publishes. Past performance does not predict future returns.

Is iShares Healthcare Innovation UCITS ETF USD (Acc) accumulating or distributing?

iShares Healthcare Innovation UCITS ETF USD (Acc) is an accumulating share class: income from its holdings is reinvested in the fund rather than paid out.

Which index does iShares Healthcare Innovation UCITS ETF USD (Acc) track?

iShares Healthcare Innovation UCITS ETF USD (Acc)'s benchmark is the STOXX GLOBAL BREAKTHROUGH HEALTHCARE (Net), which it tracks using physical replication.

Where is iShares Healthcare Innovation UCITS ETF USD (Acc) domiciled and what is its SFDR classification?

iShares Healthcare Innovation UCITS ETF USD (Acc) is domiciled in Ireland (ISIN IE00BYZK4776). It is classified under Article 8 of the EU Sustainable Finance Disclosure Regulation (SFDR).

Where does this data about iShares Healthcare Innovation UCITS ETF USD (Acc) come from?

FundFacts reads it from the documents iShares publishes for this share class — product page, factsheet, key information document and, where available, holdings and NAV files — and refreshes it every 24 hours. The same factsheet is available as JSON from the FundFacts API.

Get this factsheet as JSON

Everything on this page, plus the full holdings, every breakdown, the monthly series and the risk statistics, is one REST call. Any fund or ETF by ISIN, refreshed every 24 hours from the issuer's own documents.
curl https://fundfactsapi.com/api/v1/demo/funds/IE00BYZK4776
​
# any ISIN, with a free API key
curl https://fundfactsapi.com/api/v1/funds/IE00BYZK4776 -H "Authorization: Bearer ffk_..."
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Figures are read from the documents iShares publishes for this share class (product page, factsheet, key information document and, where available, holdings and NAV files), as of 2026-09-25. The category, risk band, concentration and tilt labels are the FundFacts profile (fundfacts-profile/3), derived from those figures with fixed, published rules. FundFacts API is independent and not affiliated with, sponsored or endorsed by iShares; fund names are used to identify the product only. Nothing on this page is investment advice.