Funds/State Street Investment Management

State Street® SPDR® MSCI World Health Care UCITS ETF

IE00BYTRRB94ETFUSDAccumulatingFigures as of 2026-09-16 · update requested
Global Blend Equity
RiskMediumValuationBlendConcentrationBalancedRegionGlobal · United States tiltSectorPharmaceuticals

State Street® SPDR® MSCI World Health Care UCITS ETF is a global blend equity etf from State Street Investment Management with a total expense ratio of 0.30% and a risk indicator of 4 on the 1–7 scale. Its ten largest positions weigh 47.8% of the portfolio, which FundFacts classifies as balanced. Regional focus: Global with a United States tilt. Sector tilt: Pharmaceuticals.

Key facts

TER0.30%
Fund sizeUSD 696m
Inception2016-04-29
Holdings111
Asset classEquities
BenchmarkMSCI World Health Care 35/20 Capped Index

Risk indicator (SRRI)

1
2
3
4
5
6
7
Lower risk · lower rewardHigher risk · higher reward
Volatility 3y13.2%
Sharpe 3y0.61
Max drawdown-17.7%

Investment objective

The objective of the Fund is to track the performance of companies in the health care sector, across developed markets globally. The Fund seeks to track the performance of the MSCI World Health Care 35/20 Capped Index (the "Index") as closely as possible.

Fund details

ISINIE00BYTRRB94
Fund houseState Street Investment Management
StructureETF
Share classUSD
Share class currencyUSD
Distribution policyAccumulating
DomicileIreland
Launch date2016-04-29
BenchmarkMSCI World Health Care 35/20 Capped Index
Asset classEquities
Fund sizeUSD 696m
Number of holdings111
Price / earnings19.0x

Fees and costs

Total expense ratio (TER)0.30%
Ongoing charges0.30%
Transaction costs0.00%
Entry charge0.00%
Exit charge0.00%
Performance fee0.00%
Reduction in yield, 1 year0.30%
Reduction in yield, holding period0.30%
Recommended holding period5 years

Growth of 100 since inception

10015020025020182020202220242026
Fund237
2016-04 → 2026-09 · rebased to 100
Computed from the NAV history the issuer publishes, monthly observations, rebased to 100 at the first point.

Calendar-year returns

+13.3%2020+19.6%2021−5.6%2022+3.6%2023+1.0%2024+14.8%2025

Annualised returns

PeriodFund
1 Year+17.36%
3 Years p.a.+7.81%
5 Years p.a.+4.42%
10 Years p.a.+8.74%
Since Inception+8.65%

Largest sectors

  1. Pharmaceuticals46.8%
  2. Biotechnology17.6%
  3. Health Care Equipment & Supplies13.9%
  4. Health Care Providers & Services13.0%
  5. Life Sciences Tools & Services8.1%
  6. Health Care Technology0.6%

Largest countries

  1. United States73.7%
  2. Switzerland9.1%
  3. United Kingdom4.8%
  4. Japan3.4%
  5. France2.1%
  6. Denmark2.0%
  7. Germany1.6%
  8. Belgium1.1%
  9. Australia0.9%
  10. Israel0.5%

Concentration

Top 10 weight 47.8% — balanced
  1. 01Eli Lilly and Company10.96%
  2. 02Johnson & Johnson7.74%
  3. 03AbbVie Inc.5.58%
  4. 04Merck & Co. Inc.4.31%
  5. 05UnitedHealth Group Incorporated4.10%
  6. 06Roche Holding Ltd3.74%
  7. 07Novartis AG3.07%
  8. 08AstraZeneca PLC2.97%
  9. 09Thermo Fisher Scientific Inc.2.91%
  10. 10Amgen Inc.2.44%
Full holdings (111) in the API payload.

Frequently asked questions

What is the TER of State Street® SPDR® MSCI World Health Care UCITS ETF?

The total expense ratio (TER) of State Street® SPDR® MSCI World Health Care UCITS ETF (IE00BYTRRB94) is 0.30% per year.

How risky is State Street® SPDR® MSCI World Health Care UCITS ETF?

State Street® SPDR® MSCI World Health Care UCITS ETF has a risk indicator (SRRI) of 4 on a scale from 1 (lower risk) to 7 (higher risk), which FundFacts places in the medium risk band. Its 3-year volatility is 13.2%. Its maximum drawdown is -17.7%.

What are the top holdings of State Street® SPDR® MSCI World Health Care UCITS ETF?

The largest positions of State Street® SPDR® MSCI World Health Care UCITS ETF as of 2026-09-16 are Eli Lilly and Company (10.96%), Johnson & Johnson (7.74%), AbbVie Inc. (5.58%), Merck & Co. Inc. (4.31%) and UnitedHealth Group Incorporated (4.10%). Its ten largest holdings make up 47.8% of the portfolio, out of 111 holdings in total.

What does State Street® SPDR® MSCI World Health Care UCITS ETF invest in?

State Street® SPDR® MSCI World Health Care UCITS ETF is a global blend equity etf. Its largest exposures as of 2026-09-16 are by country, United States 73.7%, Switzerland 9.1% and United Kingdom 4.8%; by sector, Pharmaceuticals 46.8%, Biotechnology 17.6% and Health Care Equipment & Supplies 13.9%.

How has State Street® SPDR® MSCI World Health Care UCITS ETF performed?

State Street® SPDR® MSCI World Health Care UCITS ETF returned +17.36% over one year, +4.42% a year over five years and +14.8% in calendar year 2025 as of 2026-09-16, according to the NAV history State Street Investment Management publishes. Past performance does not predict future returns.

Is State Street® SPDR® MSCI World Health Care UCITS ETF accumulating or distributing?

State Street® SPDR® MSCI World Health Care UCITS ETF is an accumulating share class: income from its holdings is reinvested in the fund rather than paid out.

Which index does State Street® SPDR® MSCI World Health Care UCITS ETF track?

State Street® SPDR® MSCI World Health Care UCITS ETF's benchmark is the MSCI World Health Care 35/20 Capped Index, which it tracks.

Where is State Street® SPDR® MSCI World Health Care UCITS ETF domiciled and what is its SFDR classification?

State Street® SPDR® MSCI World Health Care UCITS ETF is domiciled in Ireland (ISIN IE00BYTRRB94).

Where does this data about State Street® SPDR® MSCI World Health Care UCITS ETF come from?

FundFacts reads it from the documents State Street Investment Management publishes for this share class — product page, factsheet, key information document and, where available, holdings and NAV files — and refreshes it every 24 hours. The same factsheet is available as JSON from the FundFacts API.

Get this factsheet as JSON

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Figures are read from the documents State Street Investment Management publishes for this share class (product page, factsheet, key information document and, where available, holdings and NAV files), as of 2026-09-16. The category, risk band, concentration and tilt labels are the FundFacts profile (fundfacts-profile/3), derived from those figures with fixed, published rules. FundFacts API is independent and not affiliated with, sponsored or endorsed by State Street Investment Management; fund names are used to identify the product only. Nothing on this page is investment advice.